Palmitoylethanolamide, also known as PEA, is an endogenous fatty acid amide.It belongs to the family of nuclear factors agonists. It had been studies that Palmitoylethanolamide is an exogenously added or dosed compound. There are many pieces of evidence and proof that it combines with a nuclear receptor. Through this receptor, the compound exerts several biological effects. Some of these effects are even related to chronic inflammation and chronic pain.