Palmitoylethanolamide, also known as PEA, is an endogenous fatty acid amide.It belongs to the family of nuclear factors agonists. It had been studies that Palmitoylethanolamide is an exogenously added or dosed compound. There are many pieces of evidence and proof that it combines with a nuclear receptor. Through this receptor, the compound exerts several biological effects. Some of these effects are even related to chronic inflammation and chronic pain.
This component has lately emerged as one of the newest components for the treatment of pains and inflammation in humans. This component has been used for various decades by countries such as the Netherlands and other European countries. Since the 1990s, the United States of America has also become interested in Palmitoylethanolamide and it has been used to treat similar problems.
In several animal models, the researchers have found that the PEA has proven to be of clinical efficiency and can be used to treat a variety of problems such as multiple sclerosis to neuropathic pain in patients. Similar to the cannabinoids such as THC and how it has proven to be essential and effective in the treatment of neuropathic pain, the PEA serves the same purpose. The PEA has analgesic a d antihyperalgesic effects for the treatment of acute and persistent pain. This component helps in preventing nerve function and sprouting mechanical allodynia.
What are the uses of Palmitoylethanolamide?
Palmitoylethanolamide is a nutraceutical endocannabinoid. This component was retrospectively discovered in the yolk part of the eggs. PEA can also be found in various food items. For example meat, soybeans and peanuts have PEA in them.
It is very popularly known that this was used for feeding poor and malnourished children who have streptococcal infections. This is said to prevent rheumatic fever. It is also found that it is used to change the course of influenza.
Apart from the most common uses of Palmitoylethanolamide, there are not enough researches about the component. The Palmitoylethanolamide is said to only not directly activate the classic cannabinoid receptor by a great effect. Many studies show a significant amount of prospective and random trials that demonstrate and showcase that the component has pain-relieving effects when consumed. However, unlike the cannabinoids, there are fewer studies to support the theory that it can be used to treat the symptoms that are related to depression and anxiety, strokes, autism, Parkinson’s disease. Also, studies show that there are very few cases reported that show the adverse effects of PEA. In short the benefits ard greater than the side effects.
The only little side effects of this component are said to be that the person who has consumed it can experience slight heaviness in the stomach or abdomen after consumption. There is rarely any gastrointestinal discomfort or problems such as diarrhea after the use pyrroloquinoline quinone disodium salt . It is a specialized component that is now being used for medicinal purposes for the treatment of chronic pain.
Generally, the initial results are shown within two months after the regular consumption of Palmitoylethanolamide. Depending on various other factors, the results may vary from person to person.